High hierarchy

B cells

Low hierarchy

Naive B cells


mature B lymphocytes which express cell-surface IgM and IgD and have not been exposed to/activated by antigens

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HCA Immune 2018
Jaitin et al. 2019
James et al. 2020
Madissoon et al. 2020
Park et al. 2020
Vento-Tormo et al. 2018
Zheng et al. 2017


  • Blood
  • Bone marrow
  • Colon
  • Decidua
  • Mesenteric lymph node
  • Oesophagus
  • Omentum adipose tissue
  • Spleen
  • Thymus

Ontology CL:0000788